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the chemical structure of methotrexate is attracted to an enzyme in growing cells that is essential to folic acid synthesis.

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azathioprine and methotrexate have simi-lar efficacy in these disorders, and the choice of which to use may depend on tolerability board reviewor other comorbid conditions.

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although methotrexate was only approved for ra treatment in the us in 1988, it had already been used to treat cancer and psoriasis.

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